Henry Brem Selected Research

Drug Therapy (Chemotherapy)

11/2019	Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor.
1/2018	Targeted Local Therapy for Management of Intracranial High-Grade Gliomas.
10/2017	Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats.
8/2017	Risk Factors for Preoperative Seizures and Loss of Seizure Control in Patients Undergoing Surgery for Metastatic Brain Tumors.
12/2016	Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM.
2/2016	The effect of regadenoson-induced transient disruption of the blood-brain barrier on temozolomide delivery to normal rat brain.
1/2016	The Johns Hopkins Hunterian Laboratory Philosophy: Mentoring Students in a Scientific Neurosurgical Research Laboratory.
10/2015	Central Nervous System Cancers, Version 1.2015.
1/2015	Interstitial chemotherapy for malignant glioma: Future prospects in the era of multimodal therapy.
1/2015	Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response.

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Henry Brem Research Topics

Disease

98	Neoplasms (Cancer) 01/2024 - 02/2002
73	Glioma (Gliomas) 01/2024 - 02/2002
53	Brain Neoplasms (Brain Tumor) 01/2024 - 07/2002
40	Glioblastoma (Glioblastoma Multiforme) 01/2024 - 06/2002
23	Gliosarcoma 01/2022 - 02/2002
7	Melanoma (Melanoma, Malignant) 02/2022 - 12/2002
6	Wounds and Injuries (Trauma) 02/2021 - 05/2003
5	Infections 01/2023 - 01/2004
5	Pulmonary Embolism 01/2023 - 10/2008
5	Surgical Wound Infection 01/2023 - 10/2008
5	Meningioma (Meningiomas) 03/2022 - 06/2002
5	Astrocytoma (Pilocytic Astrocytoma) 11/2020 - 06/2002
5	Seizures (Absence Seizure) 08/2017 - 02/2005
4	Hydrocephalus (Hydrocephaly) 08/2023 - 01/2006
4	Venous Thrombosis (Deep-Vein Thrombosis) 01/2023 - 10/2008
4	Neoplasm Metastasis (Metastasis) 01/2022 - 01/2004
3	Hepatitis C 01/2020 - 01/2018
3	Breast Neoplasms (Breast Cancer) 01/2019 - 09/2007
3	Edema (Dropsy) 06/2018 - 07/2002
3	Oligodendroglioma 09/2013 - 06/2002
2	Hyperglycemia 04/2022 - 05/2010
2	Thrombosis (Thrombus) 01/2022 - 03/2009
2	Rhabdoid Tumor (Rhabdoid Tumors) 09/2021 - 01/2018
2	Hematologic Neoplasms (Hematological Malignancy) 02/2021 - 01/2020
2	Medulloblastoma 02/2021 - 01/2021
2	Pain (Aches) 10/2018 - 03/2007
2	Spinal Cord Neoplasms (Spinal Cord Tumors) 08/2015 - 08/2005
2	Corneal Neovascularization 01/2015 - 11/2005
2	Adenocarcinoma 11/2014 - 12/2013
2	Renal Cell Carcinoma (Grawitz Tumor) 07/2011 - 09/2007
2	Brain Edema (Cerebral Edema) 03/2009 - 07/2002
2	Neurologic Manifestations (Neurological Manifestations) 09/2007 - 01/2004
1	Hemorrhagic Fever with Renal Syndrome (HFRS) 01/2024

Drug/Important Bio-Agent (IBA)

29	PolymersIBA 02/2015 - 02/2002
27	Temozolomide (Temodar)FDA LinkGeneric 01/2024 - 10/2005
27	Carmustine (FIVB)FDA Link 11/2019 - 02/2002
11	poliferprosan 20 drug combination carmustine (Gliadel)FDA Link 01/2019 - 01/2004
9	Paclitaxel (Taxol)FDA LinkGeneric 01/2023 - 06/2002
8	Proteins (Proteins, Gene)FDA Link 08/2023 - 03/2007
6	CytokinesIBA 01/2024 - 08/2003
6	decanedioic acid- 4,4'- (1,3- propanediylbis(oxy))bis(benzoic acid) copolymerIBA 02/2013 - 02/2002
5	Biomarkers (Surrogate Marker)IBA 01/2021 - 08/2006
5	Interleukin-2 (IL2)IBA 11/2012 - 04/2003
5	Antineoplastic Agents (Antineoplastics)IBA 08/2009 - 02/2002
4	Dexamethasone (Maxidex)FDA LinkGeneric 04/2022 - 01/2004
4	Ribavirin (Virazole)FDA LinkGeneric 02/2021 - 01/2018
4	Monoclonal AntibodiesIBA 12/2018 - 01/2016
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2017 - 12/2012
4	DNA (Deoxyribonucleic Acid)IBA 08/2015 - 03/2003
4	Alkylating AgentsIBA 01/2015 - 10/2004
3	Immune Checkpoint InhibitorsIBA 02/2022 - 01/2018
3	Glutamic Acid (Glutamate)FDA Link 02/2022 - 10/2013
3	Programmed Cell Death 1 ReceptorIBA 02/2022 - 12/2016
3	Antiviral Agents (Antivirals)IBA 02/2021 - 01/2019
3	Therapeutic UsesIBA 01/2021 - 01/2016
3	Cisplatin (Platino)FDA LinkGeneric 10/2017 - 06/2002
3	Bevacizumab (Avastin)FDA Link 10/2017 - 07/2012
3	AntigensIBA 12/2016 - 01/2014
3	EndostatinsIBA 01/2015 - 11/2005
3	Doxorubicin (Adriamycin)FDA LinkGeneric 11/2014 - 09/2005
3	Anti-Bacterial Agents (Antibiotics)IBA 10/2013 - 11/2005
3	CamptothecinIBA 10/2004 - 02/2002
2	Indicators and Reagents (Reagents)IBA 01/2023 - 02/2015
2	SteroidsIBA 01/2023 - 01/2004
2	LuciferasesIBA 02/2022 - 06/2013
2	AcriflavineIBA 01/2022 - 11/2017
2	Histone MethyltransferasesIBA 09/2021 - 02/2021
2	Enhancer of Zeste Homolog 2 ProteinIBA 09/2021 - 02/2021
2	Eukaryotic Initiation Factor-4EIBA 02/2021 - 01/2020
2	Thymidine KinaseIBA 01/2020 - 02/2015
2	GuanosineIBA 01/2019 - 01/2018
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2018 - 07/2002
2	LigandsIBA 01/2018 - 06/2013
2	Dendrimers (Dendrons)IBA 12/2016 - 06/2015
2	Angiogenesis InhibitorsIBA 01/2016 - 03/2014
2	Messenger RNA (mRNA)IBA 01/2016 - 11/2013
2	Capsules (Microcapsules)IBA 11/2014 - 04/2011
2	Radiation-Sensitizing AgentsIBA 05/2014 - 08/2010
2	Minocycline (Cyclops)FDA LinkGeneric 03/2014 - 09/2003
2	Glucose (Dextrose)FDA LinkGeneric 07/2012 - 05/2010
2	EnzymesIBA 03/2010 - 03/2003
2	Irinotecan (Camptosar)FDA LinkGeneric 08/2006 - 10/2004
2	polilactofateIBA 01/2006 - 08/2003
1	AcidsIBA 01/2024
1	Lorazepam (Ativan)FDA LinkGeneric 01/2024
1	Chemokine ReceptorsIBA 01/2024

Therapy/Procedure

61	Therapeutics 01/2024 - 07/2002
26	Drug Therapy (Chemotherapy) 11/2019 - 10/2002
23	Radiotherapy 04/2021 - 01/2004
16	Immunotherapy 01/2024 - 04/2003
11	Craniotomy 01/2023 - 03/2002
4	Length of Stay 01/2024 - 08/2015
4	Microspheres (Microsphere) 05/2014 - 04/2003
3	Ventriculoperitoneal Shunt 08/2023 - 02/2005
2	Neurosurgical Procedures 01/2023 - 02/2005
2	Reoperation 09/2022 - 10/2018
2	Contraindications 10/2020 - 10/2010
2	Injections 11/2012 - 01/2012
2	Micro-Electrical-Mechanical Systems 08/2012 - 08/2005
2	Oral Administration 03/2010 - 10/2007